Envelope-Induced Cell Transformation by Ovine Betaretroviruses

Mechanisms of cell transformation induced by polyomavirus.

Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic prot...

Cell fusion induced by the murine leukemia virus envelope glycoprotein.

To determine whether ecotropic murine leukemia virus (MuLV) envelope glycoproteins are sufficient to cause cell-to-cell fusion when expressed in the absence of virus production, we used an ecotropic MuLV, AKV, to construct env expression vectors that lack the gag and pol genes. The rat cell line XC, which undergoes cell-to-cell fusion upon infection with ecotropic MuLV, was transfected with wil...

an ovine model of dilated cardiomyopathy induced by doxorubicin

background: dilated cardiomyopathy is associated with a progressive deterioration in cardiac function and eventually death. initial interest in this hypothesis was to create another large animal model for dilated cardiomyopathy in addition to pigs and dogs . methods: after the induction of anesthesia to 10 female sheep, a carotid-jugular shunt was created in all the animals via a 1-cm fistula b...

Cell Envelope Structure and Functions in Gram-negative Bacteria

Neoplastic transformation induced by carbon ions.

PURPOSE The objective of this experiment was to compare the oncogenic potential of carbon ion beams and conventional photon beams for use in radiotherapy. METHODS AND MATERIALS The HeLa X human skin fibroblast cell line CGL1 was irradiated with carbon ions of three different energies (270, 100, and 11.4 MeV/u). Inactivation and transformation data were compared with those for 15 MeV photons. ...